We all thought that this might happen in the the back of our minds, but now it's happened. With the iTunes 8.2.1 update, the Palm Pre can no longer sync with the iTunes. So if you don't want this to happen to your Pre, don't update your iTunes yet, or use third party software.
The new version of the iTunes offers: -iTunes 8.2 now supports iPhone or iPod touch with the iPhone 3.0 Software Update. iTunes 8.2 also includes many accessibility improvements and bug fixes.
-iTunes 8.2.1 provides a number of important bug fixes and addresses an issue with verification of Apple devices.